MyBioSource.com's Anti-CXCR1 antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot. The Anti-CXCR1 antibody was generated using C-C, C-C-CKR-1, CD128, CD181, CXCR1, and CXCR2 as the antigen and it reacts with Human.
Description
Description: Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 1(CXCR1) detection. Tested with WB, IHC-P in Human.
Background: CXCR1(Chemokine,CXC Motif, Receptor 1), also known as IL8RA or IL8R1, is a chemokine receptor. IL8RA is its human gene. Morris et al.(1992) mapped the IL8RA gene to chromosome 2q35. Hartl et al.(2007) concluded that CXCR1 cleavage and its functional consequences represent an important pathophysiologic mechanism in CF and other neutrophilic airway diseases. Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA(GRO) with a low affinity